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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protective efficacy of Psidium cattleianum and Myracrodruon urundeuva aqueous extracts against caries development in rats

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Author(s):
Crivelaro de Menezes, Tais Elisabete [1] ; Botazzo Delbem, Alberto Carlos [1] ; Brighenti, Fernanda Lourencao [1] ; Okamoto, Ana Claudia [2] ; Gaetti-Jardim, Jr., Elerson [2]
Total Authors: 5
Affiliation:
[1] UNESP, Sao Paulo State Univ, Dept Pediat Dent, Aracatuba - Brazil
[2] UNESP, Sao Paulo State Univ, Dept Pathol & Oral Diagnost, Aracatuba - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pharmaceutical Biology; v. 48, n. 3, p. 300-305, MAR 2010.
Web of Science Citations: 17
Abstract

This study evaluated the influence of Psidium cattleianum Sabine (Myrtaceae) and Myracrodruon urundeuva Allemao (Anacardiaceae) aqueous extracts on S. mutans counts and dental enamel micro-hardness of rats submitted to a cariogenic challenge. Sixty Wistar rats were distributed in three groups and received water (control) or aqueous extracts of Psidium cattleianum or Myracrodruon urundeuva as hydration solution. Initially the animals had their sublingual and submandibular salivary glands surgically removed and the parotid ducts ligated. Then the rats were inoculated with 10<SU6</SU CFU of Streptococcus mutans ATCC 35668 and were fed with a cariogenic diet. To detect and quantify the presence of S. mutans, oral biofilms were sampled and microbial DNA was extracted and submitted to amplification by means of real-time PCR (Polymerase Chain Reaction). After seven weeks the animals were sacrificed and enamel demineralization was analyzed by cross-sectional micro-hardness. Both extracts produced a significant reduction on S. mutans counts and decreased the enamel demineralization. It can be concluded that the extracts tested had a significant effect on S. mutans in oral biofilm of the rats, decreasing S. mutans accumulation and enamel demineralization.</. (AU)