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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction of the Anti-Inflammatory Annexin A1 Protein and Tacrolimus Immunosuppressant in the Renal Function of Rats

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Author(s):
Araujo, Leandro P. [1] ; Truzzi, Renata R. [2] ; Mendes, Gloria E. [3] ; Luz, Marcus A. M. [3] ; Burdmann, Emmanuel A. [3] ; Oliani, Sonia M. [2, 1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Postgrad Program Morphol, Sao Paulo - Brazil
[2] UNESP, IBILCE, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Jose Rio Preto Med Sch, Div Nephrol, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AMERICAN JOURNAL OF NEPHROLOGY; v. 31, n. 6, p. 527-533, 2010.
Web of Science Citations: 7
Abstract

Background: Tacrolimus (FK) is currently widely used in transplant immunosuppression and the treatment of autoimmune diseases. However, FK induces nephrotoxicity which is characterized by functional and structural renal injury. The ubiquitous protein annexin A1 (ANXA1) has potent anti-inflammatory effects and protects against ischemia/reperfusion injury. We investigated the effects of exogenous ANXA1 treatment in an experimental model of acute FK nephrotoxicity. Methods: Munich-Wistar rats received a low-salt diet for 1 week and were randomized to treatment with ANXA1 (Ac2-26 peptide 0.5 mg/kg/day s.c.), FK (6 mg/kg/day p.o.), association (FK+ANXA1) and vehicles (1 ml/kg/day) for 7 days. Results: FK induced a significant decrease in glomerular filtration rate and renal blood flow, and a significant increase in renal vascular resistance. In addition, FK caused extensive acute tubule-interstitial damage and an increase in anti-inflammatory ANXA1 expression in renal tissue. Exogenous ANXA1 treatment reduced FK-induced tubular dilatation and macrophage infiltration. For the first time, we observed that FK augmented ANXA1 expression in renal tissue. Conclusion: Exogenous ANXA1 treatment partially protected against FK-induced tubular injury and macrophage infiltration, and may be targeted in renal intervention strategies. Copyright (C) 2010 S. Karger AG, Basel (AU)

FAPESP's process: 08/01048-9 - Effects of administration of antiinflammatory annexin 1 protein in nephrotoxicity of immunossupressors cyplosporine A and tacrolimus
Grantee:Leandro Pires Araujo
Support Opportunities: Scholarships in Brazil - Master