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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure

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Author(s):
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Antunes-Correa, Ligia M. [1] ; Melo, Ruth C. [2] ; Nobre, Thais S. [1] ; Ueno, Linda M. [2] ; Franco, Fabio G. M. [1] ; Braga, Ana M. W. [1] ; Rondon, Maria U. P. B. [1] ; Brum, Patricia C. [3] ; Barretto, Antonio C. P. [1] ; Middlekauff, Holly R. [4] ; Negrao, Carlos E. [3, 1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05403904 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05403904 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05403904 Sao Paulo - Brazil
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Cardiol & Physiol, Los Angeles, CA 90095 - USA
Total Affiliations: 4
Document type: Journal article
Source: EUROPEAN JOURNAL OF HEART FAILURE; v. 12, n. 1, p. 58-65, JAN 2010.
Web of Science Citations: 28
Abstract

We compared the effects of exercise training on neurovascular control and functional capacity in men and women with chronic heart failure (HF). Forty consecutive HF outpatients from the Heart Institute, University of Sao Paulo, Brazil were divided into the following four groups matched by age: men exercise-trained (n = 12), men untrained (n = 10), women exercise-trained (n = 9), women untrained (n = 9). Maximal exercise capacity was determined from a maximal progressive exercise test on a cycle ergometer. Forearm blood flow was measured by venous occlusion plethysmography. Muscle sympathetic nerve activity (MSNA) was recorded directly using the technique of microneurography. There were no differences between groups in any baseline parameters. Exercise training produced a similar reduction in resting MSNA (P = 0.000002) and forearm vascular resistance (P = 0.0003), in men and women with HF. Peak VO(2) was similarly increased in men and women with HF (P = 0.0003) and VE/VCO(2) slope was significantly decreased in men and women with HF (P = 0.0007). There were no significant changes in left-ventricular ejection fraction in men and women with HF. The benefits of exercise training on neurovascular control and functional capacity in patients with HF are independent of gender. (AU)

FAPESP's process: 05/59740-7 - Physical exercise and autonomic control in cardiovascular physiopathology
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants