Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrophysiological correlates of sleep disturbance induced by acute and chronic administration of D-amphetamine

Full text
Author(s):
Andersen, Monica L. [1] ; Margis, Regina [2, 3] ; Frey, Benicio N. [4] ; Giglio, Larriany M. F. [2, 3] ; Kapczinski, Flavio [2, 3] ; Tufik, Sergio [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Rio Grande do Sul, Bipolar Disorders Program, Porto Alegre, RS - Brazil
[3] Univ Fed Rio Grande do Sul, Lab Mol Psychiat, Porto Alegre, RS - Brazil
[4] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON - Canada
Total Affiliations: 4
Document type: Journal article
Source: Brain Research; v. 1249, p. 162-172, JAN 16 2009.
Web of Science Citations: 5
Abstract

Sleep disturbance is the strongest predictor of manic relapse and is considered one of the most important objective measures of treatment response in bipolar disorder (BD). However, the neurobiological mechanisms underlying sleep disturbance in BD are poorly understood. The administration of psycho stimulants to rodents can trigger a number of manic-like behaviors. Therefore, the present study aims to investigate the effects of single and repeated D-amphetamine (AMPH) administration on sleep patterns in rats. Sleep was continuously monitored during light periods after single and repeated (7 days) injections of AMPH (2 mg/kg, i.p.) or saline in adult Wistar rats using electrocorticogram and electromyographic recordings. Acute injections of AMPH suppressed sleep for the first 2 h, and were followed by a gradual increase in the amount of sleep. Both slow wave sleep (SWS) and paradoxical sleep (PS) were compromised. Repeated exposure to AMPH led to a drastic disruption of the sleep-wake cycle that was mainly characterized by a decrease of PS during all time-points recorded in comparison to the saline group. Furthermore, both acute and chronic AMPH administration induced longer latencies to both SWS and PS. These findings suggest that AMPH produces profound sleep disturbances and decreases PS sleep. Given that some of these abnormalities are observed in individuals with BD, this animal model can provide a means to investigate neurobiological aspects of sleep disturbance in BD, as well as their response to mood stabilizers. (C) 2008 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC