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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondrial Network Size Scaling in Budding Yeast

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Rafelski, Susanne M. [1, 2] ; Viana, Matheus P. [3] ; Zhang, Yi [1, 4, 5] ; Chan, Yee-Hung M. [1, 2] ; Thorn, Kurt S. [1] ; Yam, Phoebe [6] ; Fung, Jennifer C. [6] ; Li, Hao [1, 2] ; Costa, Luciano da F. [3] ; Marshall, Wallace F. [1, 2]
Total Authors: 10
[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 - USA
[2] Univ Calif San Francisco, Ctr Syst & Synthet Biol, San Francisco, CA 94143 - USA
[3] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil
[4] Peking Univ, Ctr Theoret Biol, Beijing 100871 - Peoples R China
[5] Peking Univ, Sch Phys, Beijing 100871 - Peoples R China
[6] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA - USA
Total Affiliations: 6
Document type: Journal article
Source: Science; v. 338, n. 6108, p. 822-824, NOV 9 2012.
Web of Science Citations: 72

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance. (AU)

FAPESP's process: 07/50882-9 - Characterization and modeling of biological networks
Grantee:Matheus Palhares Viana
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 05/00587-5 - Mesh (graph) modeling and techniques of pattern recognition: structure, dynamics and applications
Grantee:Roberto Marcondes Cesar Junior
Support type: Research Projects - Thematic Grants