Mitochondrial Network Size Scaling in Budding Yeast

Author(s)

Rafelski, Susanne M. ^{[1, 2]} ; Viana, Matheus P. ^[3] ; Zhang, Yi ^{[1, 4, 5]} ; Chan, Yee-Hung M. ^{[1, 2]} ; Thorn, Kurt S. ^[1] ; Yam, Phoebe ^[6] ; Fung, Jennifer C. ^[6] ; Li, Hao ^{[1, 2]} ; Costa, Luciano da F. ^[3] ; Marshall, Wallace F. ^{[1, 2]}

Affiliation

^[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 - USA

^[2] Univ Calif San Francisco, Ctr Syst & Synthet Biol, San Francisco, CA 94143 - USA

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil

^[4] Peking Univ, Ctr Theoret Biol, Beijing 100871 - Peoples R China

^[5] Peking Univ, Sch Phys, Beijing 100871 - Peoples R China

^[6] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA - USA

• Document type: Journal article
• Source: Science; v. 338, n. 6108, p. 822-824, NOV 9 2012.
• Web of Science Citations: 72

Abstract

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance. (AU)

• FAPESP's process: 05/00587-5 - Mesh (graph) modeling and techniques of pattern recognition: structure, dynamics and applications
• Grantee: Roberto Marcondes Cesar Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 07/50882-9 - Characterization and modeling of biological networks
• Grantee: Matheus Palhares Viana
• Support Opportunities: Scholarships in Brazil - Doctorate