| Full text | |
| Author(s): |
de Figueiredo Nicolete, Larissa Deadame
[1, 2, 3]
;
Nicolete, Roberto
[3]
;
Haddad, Rodrigo
[4, 1]
;
Azevedo, Rochele
[1]
;
de Castro, Fabiola Attie
[2]
;
Tanaka, Yuetsu
[5, 6]
;
Takayanagui, Osvaldo Massaiti
[4]
;
Covas, Dimas Tadeu
[4, 1]
;
Kashima, Simone
[4, 1, 2]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Fundacao Hemoctr Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[3] Fiocruz Rondonia, Porto Velho, RO - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[5] Univ Ryukyus, Dept Immunol, Grad Sch, Nishihara, Okinawa 90301 - Japan
[6] Univ Ryukyus, Fac Med, Nishihara, Okinawa 90301 - Japan
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Memórias do Instituto Oswaldo Cruz; v. 107, n. 6, p. 824-827, SEP 2012. |
| Web of Science Citations: | 3 |
| Abstract | |
The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes. (AU) | |