Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

Full text
Author(s):
Estevanato, Luciana L. C. ; Da Silva, Jaqueline R. ; Falqueiro, Andre M. [1] ; Mosiniewicz-Szablewska, Ewa [2] ; Suchocki, Piotr [3, 4] ; Tedesco, Antnio C. [1] ; Morais, Paulo C. [5] ; Lacava, Zulmira G. M. [6]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Fotobiol & Fotomed, Dept Quim, Ribeirao Preto, SP - Brazil
[2] Polish Acad Sci, Inst Phys, Warsaw - Poland
[3] Warsaw Med Univ, Dept Drug Anal, Warsaw - Poland
[4] Natl Med Inst, Dept Pharmaceut Chem, Warsaw - Poland
[5] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF - Brazil
[6] Univ Brasilia, Inst Ciencias Biol, CNANO, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 7, p. 5287-5299, 2012.
Web of Science Citations: 17
Abstract

Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A) and neoplastic (4T1 and MCF-7) breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC) represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system for antitumor therapy. (AU)

FAPESP's process: 09/13208-3 - Preparation, characterization, and in vitro antitumoral activity of nanocapsules containing selol.
Grantee:André Miotello Falqueiro
Support Opportunities: Scholarships in Brazil - Master