4-Organochalcogenoyl-1H-1,2,3-triazoles: synthesis and functionalization by a nickel-catalyzed Negishi cross-coupling reaction

Stefani, Helio A.; Leal, Daiana M.; Manarin, Flavia

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

4-Organochalcogenoyl-1H-1,2,3-triazoles: synthesis and functionalization by a nickel-catalyzed Negishi cross-coupling reaction

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Author(s):	Stefani, Helio A. ^[1] ; Leal, Daiana M. ^[1] ; Manarin, Flavia ^[1] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Fac Farm, Fac Ciencias Farmaceut, BR-05508 Sao Paulo - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	Tetrahedron Letters; v. 53, n. 48, p. 6495-6499, NOV 28 2012.
Web of Science Citations:	15
Abstract
A general method for the synthesis of triazoles containing selenium and tellurium was accomplished via a CuCAAC reaction between organic azides and a terminal triple bond, generated by in situ deprotection of the silyl group. The reaction tolerates alkyl and arylazides, with alkyl and aryl substituents directly bonded to the chalcogen atom. The products were readily functionalized by a nickel-catalyzed Negishi cross-coupling reaction, furnishing the aryl-heteroaryl products at the 4-position in good yields. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process:	10/15677-8 - Synthesis of alpha-substituted styrenes
Grantee:	Flávia Giovana Manarin
Support Opportunities:	Scholarships in Brazil - Post-Doctoral

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