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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A new portal for the analysis of human splicing variants

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Author(s):
Kroll, Jose Eduardo [1, 2] ; Galante, Pedro A. F. [1] ; Ohara, Daniel T. [1] ; Navarro, Fabio C. P. [1] ; Ohno-Machado, Lucila [3] ; de Souza, Sandro J. [1]
Total Authors: 6
Affiliation:
[1] Ludwig Inst Canc Res, Lab Computat Biol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Interinst Program Bioinformat, Sao Paulo - Brazil
[3] Univ Calif San Diego, Div Biomed Informat, Bioinformat Grp, La Jolla, CA 92093 - USA
Total Affiliations: 3
Document type: Journal article
Source: RNA BIOLOGY; v. 9, n. 11, p. 1339-1343, NOV 2012.
Web of Science Citations: 8
Abstract

Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a challenge to catalog and display alternative splicing events (ASEs). Although several groups have faced this challenge with relative success, we still lack a computational tool that uses a simple and straightforward method to retrieve, name and present ASEs. Here we present SPLOOCE, a portal for the analysis of human splicing variants. SPLOOCE uses a method based on regular expressions for retrieval of ASEs. We propose a simple syntax that is able to capture the complexity of ASEs. (AU)

FAPESP's process: 09/53853-5 - Acquisition of a high-performance platform for computational analyses applied to the field of medicine
Grantee:Wilson Araújo da Silva Junior
Support type: Multi-user Equipment Program