| Full text | |
| Author(s): |
del Carmen, Rosa
[1]
;
Vargas-Rodriguez, Miluska
[1]
;
Bastos, Melissa da Silva
[1]
;
Menezes, Maria Jose
[1]
;
Orjuela-Sanchez, Pamela
[2]
;
Ferreira, Marcelo U.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil
[2] La Jolla Bioengn Inst, San Diego, CA - USA
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | American Journal of Tropical Medicine and Hygiene; v. 87, n. 5, p. 813-821, NOV 2012. |
| Web of Science Citations: | 19 |
| Abstract | |
Emerging resistance to chloroquine (CQ) poses a major challenge for Plasmodium vivax malaria control, and nucleotide substitutions and copy number variation in the P. vivax multidrug resistance 1 (pvmdr-1) locus, which encodes a digestive vacuole membrane transporter, may modulate this phenotype. We describe patterns of genetic variation in pvmdr-1 alleles from Acre and Amazonas in northwestern Brazil, and compare then with those reported in other malaria-endemic regions. The pvmdr-1 mutation Y976F, which is associated with CQ resistance in Southeast Asia and Oceania, remains rare in northwestern Brazil (1.8%) and its prevalence mirrors that of CO resistance worldwide. Gene amplification of pvmdr-1, which is associated with mefloquine resistance but increased susceptibility to CO, remains relatively rare in northwestern Brazil (0.9%) and globally (< 4%), but became common (> 10%) in Tak Province, Thailand, possibly because of drug-mediated selection. The global database we have assembled provides a baseline for further studies of genetic variation in pvmdr-1 and drug resistance in P. vivax malaria. (AU) | |
| FAPESP's process: | 10/51835-7 - Resistencia a cloroquina em plasmodium vivax: avaliacao fenotipica e molecular na amazonia ocidental brasileira |
| Grantee: | Marcelo Urbano Ferreira |
| Support Opportunities: | Regular Research Grants |