| Full text | |
| Author(s): |
Aquino, Evanirso Silva
[1, 2, 3]
;
Shimura, Francine
[2, 4]
;
Santos, Adriana Silveira
[1]
;
Goto, Danielle Miyuki
[2]
;
Coelho, Cristiane Cenachi
[3]
;
de Fuccio, Marcelo Bicalho
[3]
;
Nascimento Saldiva, Paulo Hilario
[5, 6]
;
Lorenzi-Filho, Geraldo
[7]
;
Rubin, Bruce K.
[8, 9]
;
Nakagawa, Naomi Kondo
[2, 5, 6]
Total Authors: 10
|
| Affiliation: | [1] Univ Cidade Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Physiotherapy Commun Sci & Disorders & Occup, Lab Invest Med 34, Sao Paulo - Brazil
[3] Univ Catolica Minas Gerais, Hosp Infantil Joao Paulo 2, Belo Horizonte, MG - Brazil
[4] Univ Prebiteriana Mackenzie, Dept Pharmacol, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Dept Pathol, Pulm Def Grp, Sao Paulo - Brazil
[6] Univ Sao Paulo, Fac Med, Dept Pathol, LIM 05, Sao Paulo - Brazil
[7] Univ Sao Paulo, Fac Med, Hosp Clin, Pulm Div, Heart Inst, Sao Paulo - Brazil
[8] Virginia Commonwealth Univ, Sch Med, Dept Pediat, Richmond, VA - USA
[9] Virginia Commonwealth Univ, Childrens Hosp Richmond, Richmond, VA - USA
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Respiratory Care; v. 57, n. 11, p. 1914-1919, NOV 2012. |
| Web of Science Citations: | 5 |
| Abstract | |
BACKGROUND: Positive expiratory pressure (PEP) is used for airway clearance in cystic fibrosis (CF) patients. Hypertonic saline (HTS) aerosol increases sputum expectoration volume and may improve respiratory secretion properties. CPAP may also be used to maintain airway patency and mobilize secretions. To evaluate if CPAP would increase the beneficial clearance effect of HTS in subjects with CF, we investigated the effects of CPAP alone and CPAP followed by HTS on sputum physical properties and expectoration volume in CF subjects. METHODS: In this crossover study, 15 CF subjects (mean age 19 y old) were randomized to interventions, 48 hours apart: directed coughs (control), CPAP at 10 cm H2O, HTS 7%, and both CPAP and HTS (CPAP+HTS). Sputum collection was performed at baseline and after interventions. Expectorated volume was determined and in vitro sputum properties were analyzed for contact angle and cough clearability. RESULTS: There were no significant differences between any treatment in arterial blood pressure, heart rate, or pulse oximetry, between the 2 time points. HTS and CPAP+HTS improved cough clearability by 50% (P = .001) and expectorated volume secretion by 530% (P = .001). However, there were no differences between control and CPAP on sputum contact angle, cough clearability, or volume of expectorated secretion. CONCLUSIONS: CPAP alone had no effect on mucus clearance, sputum properties, or expectorated volume, and did not potentiate the effect of HTS alone in CF subjects. (AU) | |