| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 41, p. 6-10, MAR 5 2013. |
| Web of Science Citations: | 10 |
| Abstract | |
Increased anxiety is a classic effect of sleep deprivation. However, results regarding sleep deprivation-induced anxiety-like behavior are contradictory in rodent models. The grooming analysis algorithm is a method developed to examine anxiety-like behavior and stress in rodents, based on grooming characteristics and microstructure. This study evaluated the applicability of the grooming analysis algorithm to distinguish sleep-deprived and control rats in comparison to traditional grooming analysis. Forty-six animals were distributed into three groups: control (n=22), paradoxical sleep-deprived (96 h, n=10) and total sleep deprived (6 h, n=14). Immediately after the sleep deprivation protocol, grooming was evaluated using both the grooming analysis algorithm and traditional measures (grooming latency, frequency and duration). Results showed that both paradoxical sleep-deprived and total sleep-deprived groups displayed grooming in a fragmented framework when compared to control animals. Variables from the grooming analysis algorithm were successful in distinguishing sleep-deprived and normal sleep animals regarding anxiety-like behavior. The grooming analysis algorithm and traditional measures were strongly correlated. In conclusion, the grooming analysis algorithm is a reliable method to assess the relationship between anxiety-like behavior and sleep deprivation. (C) 2012 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 10/14768-0 - EFFECT OF SLEEP RESTRICTION DURING PREGNANCY ON MATERNAL BEHAVIOR IN RATS |
| Grantee: | Gabriel Natan de Souza Pires |
| Support Opportunities: | Scholarships in Brazil - Master |