Bayesian Prediction and Evaluation in the Anterior Cingulate Cortex

Author(s)

Ide, Jaime S. ^[1] ; Shenoy, Pradeep ^[2] ; Yu, Angela J. ^[2] ; Li, Chiang-shan R. ^{[1, 3, 4]}

Affiliation

^[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 - USA

^[2] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 - USA

^[3] Yale Univ, Sch Med, Interdept Neurosci Program, New Haven, CT 06520 - USA

^[4] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 - USA

• Document type: Journal article
• Source: JOURNAL OF NEUROSCIENCE; v. 33, n. 5, p. 2039-2047, JAN 30 2013.
• Web of Science Citations: 95

Abstract

The dorsal anterior cingulate cortex (dACC) has been implicated in a variety of cognitive control functions, among them the monitoring of conflict, error, and volatility, error anticipation, reward learning, and reward prediction errors. In this work, we used a Bayesian ideal observer model, which predicts trial-by-trial probabilistic expectation of stop trials and response errors in the stop-signal task, to differentiate these proposed functions quantitatively. We found that dACC hemodynamic response, as measured by functional magnetic resonance imaging, encodes both the absolute prediction error between stimulus expectation and outcome, and the signed prediction error related to response outcome. After accounting for these factors, dACC has no residual correlation with conflict or error likelihood in the stop-signal task. Consistent with recent monkey neural recording studies, and in contrast with other neuroimaging studies, our work demonstrates that dACC reports at least two different types of prediction errors, and beyond contexts that are limited to reward processing. (AU)

• FAPESP's process: 11/08573-4 - Functional connectivity analysis of drug-resistant epilepsy patients submitted to epilepsy surgery
• Grantee: Jaime Shinsuke Ide
• Support Opportunities: Research Grants - Young Investigators Grants