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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

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Author(s):
Izar, Maria C. [1, 2] ; Fonseca, Henrique A. [1] ; Pinheiro, Luiz F. [1] ; Monteiro, Carlos M. [1] ; Povoa, Rui M. [1] ; Monteiro, Andrea M. [3, 2] ; Figueiredo-Neto, Antonio M. [2] ; Gidlund, Magnus A. [3] ; Fonseca, Francisco A. [1, 2]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Paulo, Dept Med, Div Cardiol, BR-04039030 Sao Paulo - Brazil
[2] Univ Sao Paulo, Natl Inst Complex Fluids, Inst Phys, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Diabetes & Vascular Disease Research; v. 10, n. 1, p. 32-39, JAN 2013.
Web of Science Citations: 9
Abstract

Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS. (AU)