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Molecular markers as predictors of cardiovascular events incidence after acute coronary syndrome


Acute Coronary Syndromes (ACS) are characterized as a set of clinical symptoms compatible with acute myocardial ischemia and were responsible only in the year 2009 by more than 208,000 hospitalizations in the unified health system (SUS). The mechanisms that involve the occurrence of an event of ACS began with the formation and subsequent disruption of an atheromatous plaque and are related to intravascular thrombus formation, and in both cases partial or total artery occlusion are responsible for the myocardial ischemia. Because it is an inheritable and multifactorial disease, genetic association studies are important tools to define molecular markers for event prediction and prognosis in ACS. Therefore, the objective of this project is to validate 63 candidate polymorphic markers described in recently published GWAS as associated with CAD or cardiovascular risk factors and correlate them with the occurrence of cardiovascular events incidence in a one-year follow-up period. In addition, we will evaluate the expression of genes validated in two stages: at the time of first event and 30 days later, during treatment. We will study subjects of both sexes, regardless of age, with a confirmed diagnosis of ACS in the Emergency Room of the University of São Paulo's Hospital. For this, will use multiplex RT-PCR for genotyping, and RNA extraction with TRIzol ®, reverse transcription and quantitative real time PCR (qRT-PCR) to evaluate the expression of candidate genes in the two periods the study. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIOLI-PEREIRA, LUCIANA; JUNIOR LIMA SANTOS, PAULO CALEB; FERREIRA, NOELY EVANGELISTA; HUEB, WHADY ARMINDO; KRIEGER, JOSE EDUARDO; PEREIRA, ALEXANDRE COSTA. Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21. BMC CARDIOVASCULAR DISORDERS, v. 12, AUG 2 2012. Web of Science Citations: 11.
SANTOS, PAULO C. J. L.; OLIVEIRA, THEO G. M.; LEMOS, PEDRO A.; MILL, JOSE G.; KRIEGER, JOSE E.; PEREIRA, ALEXANDRE C. MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population. LIPIDS IN HEALTH AND DISEASE, v. 11, JUN 28 2012. Web of Science Citations: 12.

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