Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families

Author(s)

Gadelha, Ary ^{[1, 2]} ; Ota, Vanessa Kiyomi ^{[1, 2, 3]} ; Cano, Jose Paya ^[4] ; Melaragno, Maria Isabel ^[3] ; Smith, Marilia A. C. ^[3] ; Mari, Jair de Jesus ^{[1, 2]} ; Bressan, Rodrigo A. ^{[1, 2]} ; Belangero, Sintia Iole ^{[1, 2, 3]} ; Breen, Gerome ^{[4, 5]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Schizophrenia Program PROESQ, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Morphol & Genet Dept, Sao Paulo - Brazil

^[4] Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London WC2R 2LS - England

^[5] Kings Coll London, Inst Psychiat, Natl Inst Hlth Res Biomed Res, Ctr Mental Hlth, London WC2R 2LS - England

• Document type: Journal article
• Source: PLoS One; v. 7, n. 12 DEC 31 2012.
• Web of Science Citations: 2

Abstract

We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN (R) software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia. (AU)

• FAPESP's process: 11/00030-1 - Association study of endocannabinoid system and schizophrenia
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants