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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis: Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States

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Author(s):
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Zanchi, Nelo Eidy [1, 2, 3] ; Guimaraes-Ferreira, Lucas [1] ; de Siqueira-Filho, Mario Alves [1] ; Felitti, Vitor [3] ; Nicastro, Humberto [3] ; Bueno, Jr., Carlos [4] ; Lira, Fabio Santos [2] ; Naimo, Marshall Alan [5] ; Campos-Ferraz, Patricia [3] ; Nunes, Maria Tereza [1] ; Seelaender, Marilia [2] ; de Oliveira Carvalho, Carla Roberta [1] ; Blachier, Francois [6] ; Lancha, Jr., Antonio Herbert [3]
Total Authors: 14
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Appl Nutr & Metab, BR-05508030 Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biosci, Human Genome Res Ctr, BR-05508900 Sao Paulo - Brazil
[5] Univ Tampa, Dept Hlth Sci & Human Performance, Tampa, FL 33606 - USA
[6] INRA, CRNH IdF, UMR 914, F-78350 Paris - France
Total Affiliations: 6
Document type: Journal article
Source: NUTRIENTS; v. 4, n. 12, p. 1851-1867, DEC 2012.
Web of Science Citations: 11
Abstract

Dexamethasone (DEXA) is a potent immunosupressant and anti-inflammatory agent whose main side effects are muscle atrophy and insulin resistance in skeletal muscles. In this context, leucine supplementation may represent a way to limit the DEXA side effects. In this study, we have investigated the effects of a low and a high dose of leucine supplementation (via a bolus) on glucose homeostasis, muscle mass and muscle strength in energy-restricted and DEXA-treated rats. Since the leucine response may also be linked to the administration of this amino acid, we performed a second set of experiments with leucine given in bolus (via gavage) versus leucine given via drinking water. Leucine supplementation was found to produce positive effects (e. g., reduced insulin levels) only when administrated in low dosage, both via the bolus or via drinking water. However, under DEXA treatment, leucine administration was found to significantly influence this response, since leucine supplementation via drinking water clearly induced a diabetic state, whereas the same effect was not observed when supplied via the gavage. (AU)