Antifungal piperolides from Piper malacophyllum (Prels) C. DC.

Author(s)

João Henrique G. Lago ; Tatiane M. Tanizaki ^[2] ; Maria Claudia M. Young ^[3] ; Elsie F. Guimarães ^[4] ; Massuo J. Kato ^[5]

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 16, n. 2, p. 153-156, 2005-04-00.

Abstract

Bioactivity-guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6-dimethoxy-5-E-phenylbutenolide (1) and 4,6-dimethoxy-5-Z-phenylbutenolide (2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/1.0 mug (1) and 5.0/10.0 mug (2), respectively. (AU)

• FAPESP's process: 98/05074-0 - Conservation and sustainable use of the plant biodiversity from the Cerrado and the Atlantic Forest: chemical diversity and prospecting for potential drugs
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants