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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Normal pattern of intraepidermal nerve fibers in 30 healthy volunteers with PGP 9.5

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Author(s):
Luciana Moura [1] ; Acary Souza Bulle Oliveira [2] ; Edmar Zanoteli [3] ; Ricardo Cardoso [4] ; Beny Schmidt [5] ; Alberto Alain Gabbai [6]
Total Authors: 6
Affiliation:
[1] Universidade Federal de São Paulo. Escola Paulista de Medicina
[2] Universidade Federal de São Paulo. Escola Paulista de Medicina. Setor de Investigação em Doenças Neuromusculares
[3] Universidade Federal de São Paulo. Escola Paulista de Medicina
[4] Faculdade Metropolitana Unida
[5] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Anatomia Patológica
[6] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Neurologia e Neurocirurgia
Total Affiliations: 6
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 62, p. 271-275, 2004-06-00.
Abstract

Skin biopsy has become an attractive technique to evaluate the terminal regions of small nerve fibers. There is extensive innervation of the skin by both sensory and autonomic fibers as demonstrated by staining for the pan-axonal marker PGP 9,5. The normal pattern is fundamental before any study, since three different techniques described in the literature with different results. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg of 30 healthy controls. Median intraepidermal nerve fiber density was 5.3/mm. Skin biopsy may be a useful tool for assessing the topographic extent and degree of nerve fiber damage in sensory neuropathies and may be particularly useful in experimental treatment trials for peripheral neuropathies since, in contrast to standard nerve biopsy, the test can be repeated. (AU)