Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Probing the binding of tetraplatinum(pyridyl)porphyrin complexes to DNA by means of surface plasmon resonance

Full text
Author(s):
Naue, Jeferson A. [1] ; Toma, Sergio H. [1] ; Bonacin, Juliano A. [1] ; Araki, Koiti [1] ; Toma, Henrique E. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Quim, BR-05513970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Inorganic Biochemistry; v. 103, n. 2, p. 182-189, Feb. 2009.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Web of Science Citations: 13
Abstract

Tetrapyridylporphyrins containing four chloro(2,2'-bipyridine)platinum(II) complexes attached at the meta (3-H2TPtPyP) and para (4-H2TPtPyP) positions of the peripheral pyridine ligands were synthesized and their interaction with DNA investigated. The compounds were isolated in the solid state and characterized by means of spectroscopic and analytical techniques. According to molecular simulations, the two isomers exhibit contrasting structural characteristics, consistent with a saddle shape configuration for 3-H2TPtPyP and a planar geometry for 4-H2TPtPyP. Surface plasmon resonance studies were carried out on the interaction of the complexes with calf thymus DNA, revealing a preferential binding of 3-H2TPtPyP, presumably at the DNA major grooves. (AU)

FAPESP's process: 00/06560-8 - Development of supramolecular metal-organic chemistry and devices
Grantee:Henrique Eisi Toma
Support Opportunities: Research Projects - Thematic Grants