| Full text | |
| Author(s): |
Rui Curi
[1]
;
Cláudia J. Lagranha
[2]
;
Jair Rodrigues G. Jr
[3]
;
Tania Cristina Pithon-Curi
;
Antonio Herbert Lancha Jr
[5]
;
Ídico L. Pellegrinotti
[6]
;
Joaquim Procopio
[7]
Total Authors: 7
|
| Affiliation: | [1] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Fisiologia e Biofísica
[2] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Fisiologia e Biofísica
[3] Universidade Estadual Paulista 'Julio de Mesquita Filho'. Departamento de Educação Física
[5] Universidade de São Paulo. Departamento de Biodinâmica do Movimento do Corpo Humano. Escola de Educação Física
[6] Universidade Metodista de Piracicaba. FACEF
[7] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Fisiologia e Biofísica
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Endocrinologia e Metabologia; v. 47, n. 2, p. 135-143, 2003-04-00. |
| Abstract | |
Fatty acids are important fuels for muscle during moderate and prolonged exercise. The utilization of fatty acids by skeletal muscle depends on important key steps such as lipolysis in the adipose tissue, plasma fatty acids transport, and passage through plasma and mitochondrial membranes, beta-oxidation, and finally oxidation through the Krebs cycle and respiratory chain activity. Acute exercise and exercise training induce adaptations that lead to an increase in fatty acid oxidation. As a result muscle glycogen is preserved. Nevertheless, diet manipulation and supplementation with lipolytic agents that raise fatty acids mobilization and oxidation during exercise failed to show beneficial results on exercise performance. The hypothesis that Krebs cycle is a limiting factor for fatty acid oxidation by the skeletal muscle during prolonged exercise is presented herein. (AU) | |