Synthesis and biological activity of three new 5a-hydroxy spirostanic brassinosteroid analogues

Author(s)

Caridad R. Rodríguez ^[1] ; Yohan I. Villalobos ^[2] ; Esther A. Becerra ^[3] ; Francisco C. Manchado ^[4] ; Deysma C. Herrera ^[5] ; Marco A. T. Zullo ^[6]

Affiliation

^[1] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[2] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[3] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[4] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[5] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[6] Instituto Agronômico. Laboratório de Fitoquímica - Brasil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 14, n. 3, p. 466-469, 2003-05-00.

Abstract

Three new spirostanic brassinosteroid analogues have been synthesized for the first time from diosgenin: (25R)-2alpha,3alpha-epoxy-5alpha-hydroxyspirostan-6-one (3), (25R)-2beta,3alpha,5alpha-trihydroxyspirostan-6-one (5) and (25R)-2beta-methoxy-3alpha,5alpha-dihydroxyspirostan-6-one (6). In the radish hypocotyl elongation and cotyledon expansion bioassay compound 3 showed plant growth promoting activity whereas 6 was shown to be phytotoxic. (AU)

• FAPESP's process: 99/09687-0 - Caridad Robaina Rodriguez | University of Havana - Cuba
• Grantee: Marco António Teixeira Zullo
• Support Opportunities: Research Grants - Visiting Researcher Grant - International