RCPedia: a database of retrocopied genes

Author(s)

Navarro, Fabio C. P. ^{[1, 2]} ; Galante, Pedro A. F. ^[1]

Affiliation

^[1] Hosp Sirio Libanes, Ctr Mol Oncol, BR-01308060 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Bioquim, BR-05508000 Sao Paulo - Brazil

• Document type: Journal article
• Source: Bioinformatics; v. 29, n. 9, p. 1235-1237, MAY 1 2013.
• Web of Science Citations: 13

Abstract

Motivation: Retrocopies are copies of mature RNAs that are usually devoid of regulatory sequences and introns. They have routinely been classified as processed pseudo-genes with little or no biological relevance. However, recent findings have revealed functional roles for retrocopies, as well as their high frequency in some organisms, such as primates. Despite their increasing importance, there is no user-friendly and publicly available resource for the study of retrocopies. Results: Here, we present RCPedia, an integrative and user-friendly database designed for the study of retrocopied genes. RCPedia contains a complete catalogue of the retrocopies that are known to be present in human and five other primate genomes, their genomic context, inter-species conservation and gene expression data. RCPedia also offers a streamlined data representation and an efficient query system. (AU)

• FAPESP's process: 12/24731-1 - Retrocopies: origins, polymorphism and somatic variations
• Grantee: Pedro Alexandre Favoretto Galante
• Support Opportunities: Research Grants - Young Investigators Grants