Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage

Full text
Author(s):
Picao, Renata C. [1, 2] ; Cardoso, Juliana P. [2] ; Campana, Eloiza H. [2] ; Nicoletti, Adriana G. [2] ; Petrolini, Fernanda V. B. [2] ; Assis, Diego M. [3, 4] ; Juliano, Luiz [3] ; Gales, Ana C. [2]
Total Authors: 8
Affiliation:
[1] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio De Janeiro - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Infectol, Lab ALERTA, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo - Brazil
[4] Fundacao Parque Zool Sao Paulo, Lab Microbiol Aplicada, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 76, n. 1, p. 80-85, MAY 2013.
Web of Science Citations: 61
Abstract

We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. The presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/11051-0 - Antimicrobial resistance in water samples: the role of natural reservoirs in the acquisition of resistance genes and the role of the hospital effluent in the dissemination of antimicrobial resistant pathogens
Grantee:Renata Cristina Picão
Support Opportunities: Scholarships in Brazil - Post-Doctoral