Emergence of pathogenicity in the Sporothrix schen... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emergence of pathogenicity in the Sporothrix schenckii complex

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Author(s):
Rodrigues, Anderson Messias [1, 2] ; De Hoog, Sybren [1] ; De Camargo, Zoilo Pires [2]
Total Authors: 3
Affiliation:
[1] CBS KNAW Fungal Biodivers Ctr, Utrecht - Netherlands
[2] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Cellular Biol Div, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Medical Mycology; v. 51, n. 4, p. 405-412, MAY 2013.
Web of Science Citations: 76
Abstract

Sporothrix schenckii sensu lato is a complex of thermally dimorphic species whose natural habitats are soil and plant materials. However, the traumatic implantation of the species into human skin is traditionally thought to be the route leading to the fungal disease sporotrichosis. The complex contains Sporotrhix mexicana, S. globosa, S. brasiliensis, S. luriei, in addition to S. schenckii sensu stricto. In this study we evaluated the differences among these species relative to their frequency in the environment and in human hosts, as well as discuss their remarkable diverse pathogenicity. Today, S. brasiliensis is epidemic in and geographically restricted to Brazil. In contrast, S. mexicana and S. globosa have rarely been reported over the decades. We discovered that the species have been present in collections from clinical cases since 1955 and were able to re-identify six isolates originally classified as S. schenckii as Sporothrix mexicana (three isolates) and Sporothrix globosa (three isolates). Despite their long presence as potential human pathogens they have not shown any increase in frequency as etiologic agents of human infections. (AU)

FAPESP's process: 11/07350-1 - Biology of Sporothrix schenckii complex: Analysis of molecular and proteomics markers, and the role of antigenic and antifungal molecules in sporotrichosis
Grantee:Anderson Messias Rodrigues
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/54024-2 - Molecular biology and proteomics of medically interesting fungi: Paracoccidioides brasiliensis and Sporothrix schenckii
Grantee:Zoilo Pires de Camargo
Support Opportunities: Research Projects - Thematic Grants