| Full text | |
| Author(s): |
Alexandrino-Silva, Clovis
[1]
;
Wang, Yuan-Pang
[1]
;
Viana, Maria Carmen
[1]
;
Bulhoes, Rodrigo S.
[2]
;
Martins, Silvia S.
[3]
;
Andrade, Laura Helena
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sect Psychiat Epidemiol LIM 23, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo - Brazil
[3] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY - USA
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Affective Disorders; v. 147, n. 1-3, p. 355-364, MAY 2013. |
| Web of Science Citations: | 32 |
| Abstract | |
Background: Few studies have investigated symptomatic subtypes of depression and their correlates by gender. Methods: Data are from the Sao Paulo Megacity Mental Health Survey. Symptom profiles of 1207 subjects (864 women; 343 men) based upon symptoms of the worst depressive episode in lifetime were examined through latent class analysis. Correlates of gender-specific latent classes were analyzed by logistic regression. Results: For both men and women, a 3-class model was the best solution. A mild class was found in both genders (41.1% in women; 40.1% in men). Gender differences appeared in the most symptomatic classes. In women, they were labeled melancholic (39.3%) and atypical (19.5%), differing among each other in somatic/vegetative symptoms. The melancholic class presented inhibition and eating/sleeping symptoms in the direction of decreasing, whereas the atypical class had increased appetite/weight, and hypersomnia. For men, symptoms that differentiate the two most symptomatic classes were related to psychomotor activity: a melancholic/psychomotor retarded (40.4%) and agitated depression (19.6%). The highest between-class proportion of agitation and racing thoughts was found among men in the agitated class, with similarity to bipolar mixed state. Limitations: Analyses were restricted to those who endorsed questions about their worst lifetime depressive episode; the standardized assessment by lay interviewers; the small male sample size. Conclusions: The construct of depression of current classifications is heterogeneous at the symptom level, where gender different subtypes can be identified. These symptom profiles have potential implications for the nosology and the therapeutics of depression. (C) 2012 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 03/00204-3 - Epidemiological study of psychiatric disorders in the São Paulo Metropolitan Region: prevalence, risk factors, and social and economical burden |
| Grantee: | Laura Helena Silveira Guerra de Andrade |
| Support Opportunities: | Research Projects - Thematic Grants |