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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Normal Weight Obesity Is Associated with Metabolic Syndrome and Insulin Resistance in Young Adults from a Middle-Income Country

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Author(s):
Madeira, Francilene B. [1] ; Silva, Antonio A. [2] ; Veloso, Helma F. [2] ; Goldani, Marcelo Z. [3] ; Kac, Gilberto [4] ; Cardoso, Viviane C. [5] ; Bettiol, Heloisa [5] ; Barbieri, Marco A. [5]
Total Authors: 8
Affiliation:
[1] Univ Estadual Piaui, Phys Educ Undergrad Course, Teresina - Brazil
[2] Univ Fed Maranhao, Dept Publ Hlth, Sao Luis - Brazil
[3] Univ Fed Rio Grande do Sul, Fac Med, Dept Pediat & Puericulture, Porto Alegre, RS - Brazil
[4] Univ Fed Rio de Janeiro, Josue de Castro Nutr Inst, Dept Social & Appl Nutr, Rio De Janeiro - Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Puericulture & Pediat, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PLoS One; v. 8, n. 3 MAR 28 2013.
Web of Science Citations: 50
Abstract

Objective: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. Design and Methods: The sample involved 1,222 males and females from the 1978/79 Ribeirao Preto birth cohort, Brazil, aged 23-25 years. NWO was defined as body mass index (BMI) within the normal range (18.5-24.9 kg/m(2)) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) >23% in men and >30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. Results: In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84-16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95% CI 1.57-9.28), low insulin sensitivity (OR = 3.89; 95% CI 2.39-6.33), and high insulin secretion (OR = 2.17; 95% CI 1.24-3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95% CI 5.09-14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95% CI 1.11-2.47) and high triglyceride levels (OR = 1.93; 95% CI 1.02-3.64). Most estimates changed little after further adjustment for early and adult life variables. Conclusions: NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries. (AU)

FAPESP's process: 00/09508-7 - From perinatal health to health of the young adult: study of cohort born in 1978/79 in the hospitals of Ribeirão Preto, SP
Grantee:Marco Antonio Barbieri
Support Opportunities: Research Projects - Thematic Grants