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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep and epilepsy: Exploring an intriguing relationship with a translational approach

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Author(s):
Matos, Gabriela [1] ; Tufik, Sergio [1] ; Scorza, Fulvio A. [2] ; Cavalheiro, Esper A. [2] ; Andersen, Monica L. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Expt Neurol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Epilepsy & Behavior; v. 26, n. 3, p. 405-409, MAR 2013.
Web of Science Citations: 17
Abstract

The relationship between sleep and epilepsy has been well established. There is a high prevalence of sleep disturbances in epilepsy, which are associated with a decreased quality of life of individuals with epilepsy. In view of this fact, preclinical research is necessary to address many gaps in knowledge. For instance, it is well known that sleep deprivation can trigger seizures; however, this is a complex pathophysiological event. In this context, there are many valuable animal models of epilepsy that reproduce clinical symptoms and can be used. Investigations using animal models that simulate clinical epilepsy are imperative. Furthermore, preclinical studies that reveal mechanisms related to sleep-epilepsy interactions are very important. Results of such studies can, in turn, improve the understanding of epilepsy itself and can be useful in developing new antiepileptic drugs and preventive measures to control seizures. Preclinical research should be performed using a translational framework with experimental designs that can lead to advances in the quality of life of individuals with epilepsy. In view of the fact that more than 50 million of people are affected by epilepsy around the world, understanding the relationship between sleep and epilepsy is imperative. This article is part of a Special Issue entitled ``The Future of Translational Epilepsy Research{''}. (c) 2012 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/15110-8 - Sleep and sudden unexpected death in epilepsy: possible molecular basis?
Grantee:Gabriela de Matos Barbosa Pimenta
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/05396-7 - Consequences of sleep restriction during pregnancy on the development of sensory-motor and sexual behavior in the offspring
Grantee:Monica Levy Andersen
Support type: Regular Research Grants