Relationship between oxygen consumption kinetics and BODE Index in COPD patients

Author(s)

Borghi-Silva, Audrey ^[1] ; Beltrame, Thomas ^{[1, 2]} ; Reis, Michel Silva ^[1] ; Malosa Sampaio, Luciana Maria ^[3] ; Catai, Aparecida Maria ^[1] ; Arena, Ross ^{[4, 5]} ; Costa, Dirceu ^[3]

Affiliation

^[1] Univ Fed Sao Carlos, Cardiopulm Physiotherapy Lab, BR-13560 Sao Carlos, SP - Brazil

^[2] Univ Waterloo, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1 - Canada

^[3] Univ Nove de Julho, Rehabil Sci Masters Program, Sao Paulo - Brazil

^[4] Univ New Mexico, Dept Internal Med, Div Cardiol, Div Phys Therapy, Dept Orthoped, Albuquerque, NM 87131 - USA

^[5] Univ New Mexico, Latin Amer & Iberian Inst, Albuquerque, NM 87131 - USA

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE; v. 7, p. 711-718, 2012.
• Web of Science Citations: 11

Abstract

Background and objective: Patients with chronic obstructive pulmonary disease (COPD) present with reduced exercise capacity due to impaired oxygen consumption (VO2), caused primarily by pulmonary dysfunction and deleterious peripheral adaptations. Assuming that COPD patients present with slower VO2 and heart rate (HR) on-kinetics, we hypothesized that this finding is related to disease severity as measured by the BODE Index. In this context, the present study intends to evaluate the relationship between VO2 uptake on-kinetics during high-intensity exercise and the BODE Index in patients with COPD. Methods: Twenty males with moderate-to-severe stable COPD and 13 healthy control subjects matched by age and sex were evaluated. COPD patients were screened by the BODE Index and then underwent an incremental cardiopulmonary exercise test and a constant speed treadmill session at 70% of maximal intensity for 6 minutes. The onset of the exercise (first 360 seconds) response for O-2 uptake and HR was modeled according to a monoexponential fit. Results: Oxygen consumption and HR on-kinetics were slower in the COPD group compared with controls. Additionally, VO2 on-kinetic parameters revealed a strong positive correlation (r = 0.77, P < 0.05) with BODE scores and a moderate negative correlation with walking distance (r = -0.45, P < 0.05). Conclusion: Our data show that moderate-to-severe COPD is related to impaired oxygen delivery and utilization during the onset of intense exercise. (AU)

• FAPESP's process: 09/01842-0 - Analysis of central and peripheral muscle metabolism and adjustments on dynamic versus resistance exercise in coronary arterial disease patients: effects of resistance physical training program based on anaerobic threshold by different methodologies
• Grantee: Audrey Borghi Silva
• Support Opportunities: Research Grants - Young Investigators Grants