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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The interactions and essential effects of intrinsic insulin-like growth factor-I on Leishmania (Leishmania) major growth within macrophages

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Reis, L. C. [1] ; Ramos-Sanchez, E. M. [1] ; Goto, H. [1, 2]
Total Authors: 3
[1] Univ Sao Paulo, IMTSP, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Med Prevent, Fac Med, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PARASITE IMMUNOLOGY; v. 35, n. 7-8, p. 239-244, JUL 2013.
Web of Science Citations: 10

Previously, we showed in Leishmania infections that extrinsic insulin-like growth factor (IGF)-I favored Leishmania proliferation and leishmaniasis development. In this study, the interaction of intrinsically expressed IGF-I and Leishmania (Leishmania) major in macrophages was addressed, and a key finding was the observation, using confocal microscopy, of the co-localization of IGF-I and parasites within macrophages. Following stimulation with interferon-gamma (IFN-gamma), which is known to inhibit IGF-I production in macrophages, we observed a reduction in the expression of both IGF-I mRNA and protein. This reduced expression was accompanied by a reduction in the cellular parasite load that was completely recovered with the addition of extrinsic IGF-I, which suggests an essential role for IGF-I in Leishmania growth. (AU)

FAPESP's process: 08/04106-0 - The role of insulin like-growth factor I (IGF-I) in the modulation of cytokines effect in resistance and susceptibility in murine cutaneous leishmaniasis infected by Leishmania (L.) major
Grantee:Luiza de Campos Reis
Support type: Scholarships in Brazil - Doctorate