Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy

Author(s)

Pereira, Tatiana Araujo ^[1] ; Teixeira da Silva, Gisele Espinha ^[1] ; Hernandez, Raul Bonne ^[2] ; Forti, Fabio Luis ^[1] ; Esposito, Breno Pannia ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema - Brazil

• Document type: Journal article
• Source: BIOMETALS; v. 26, n. 3, p. 439-446, JUN 2013.
• Web of Science Citations: 4

Abstract

Manganese (Mn) is an essential trace element and trivalent Mn complexes have been used as oxidation catalysts and enzyme mimetics. We studied the cytotoxicity of Mn(III) derivatives of citrate, pyrophosphate and salicylene diamine (respectively, MnCit, MnPPi and EUK8) toward HeLa cells stressed by ultraviolet irradiation and the effect of the co-administration of ascorbate and para-amino salicylate (PAS) on cell viability. Metal complexes enhanced the lethality of irradiated cells, and this effect was even more pronounced when ascorbate was co-administered with Mn(III) species. The active role of Mn(III) compounds in the antitumor activity was demonstrated by the treatment of the cells with the chelator PAS, which restored the viability of both non-irradiated and UV-irradiated cells. The association of the Mn(III) metallodrugs with radiation and an antioxidant proved to be a very effective approach to chemotherapy. (AU)

• FAPESP's process: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media
• Grantee: Ana Maria da Costa Ferreira
• Support Opportunities: Research Projects - Thematic Grants