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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The antimicrobial effect of new and conventional endodontic irrigants on intra-orally infected dentin

Full text
Author(s):
Ordinola-Zapata, Ronald [1] ; Bramante, Clovis M. [1] ; Garcia, Roberto Brandao [1] ; De Andrade, Flaviana Bombarda [1] ; Bernardineli, Norberti [1] ; De Moraes, Ivaldo Gomes [1] ; Duarte, Marco A. H. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Bauru Dent Sch Bauru, Dept Endodont, BR-05508 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ACTA ODONTOLOGICA SCANDINAVICA; v. 71, n. 3-4, p. 424-431, MAY-JUL 2013.
Web of Science Citations: 14
Abstract

Objectives. To evaluate if the incorporation of antimicrobial compounds to chelating agents or the use of chelating agents with antimicrobial activity as 7% maleic acid and peracetic acid show similar disinfection ability in comparison to conventional irrigants as sodium hypochlorite or iodine potassium iodide against biofilms developed on dentin. Materials and methods. The total bio-volume of live cells, the ratio of live cells and the substratum coverage of dentin infected intra-orally and treated with the irrigant solutions: MTAD, Qmix, Smear Clear, 7% maleic acid, 2% iodine potassium iodide, 4% peracetic acid, 2.5% and 5.25% sodium hypochlorite was measured by using confocal microscopy and the live/dead technique. Five samples were used for each irrigant solution. Results. Several endodontic irrigants containing antimicrobials as clorhexidine (Qmix), cetrimide (Smear Clear), maleic acid, iodine compounds or antibiotics (MTAD) lacked an effective antibiofilm activity when the dentin was infected intra-orally. The irrigant solutions 4% peracetic acid and 2.5-5.25% sodium hypochlorite decrease significantly the number of live bacteria in biofilms, providing also cleaner dentin surfaces (p < 0.05). Conclusions. Several chelating agents containing antimicrobials could not remove nor kill significantly biofilms developed on intra-orally infected dentin, with the exception of sodium hypochlorite and 4% peracetic acid. Dissolution ability is mandatory for an appropriate eradication of biofilms attached to dentin. (AU)

FAPESP's process: 10/16002-4 - On the chemichal and physical endodontic methods to decontaminate intraorally infected dentin
Grantee:Ronald Ordinola Zapata
Support Opportunities: Scholarships in Brazil - Doctorate