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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns

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Borelli, Karina G. [1, 2, 3] ; Albrechet-Souza, Lucas [1, 2] ; Fedoce, Alessandra G. [4] ; Fabri, Denise S. [4] ; Resstel, Leonardo B. [4] ; Brandao, Marcus L. [1, 2]
Total Authors: 6
[1] Inst Neurociencias & Comportamento, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Neuropsicofarmacol, Ribeirao Preto, SP - Brazil
[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Nucleo Cognicao & Sistemas Complexos, Santo Andre, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Hormones and Behavior; v. 63, n. 5, p. 791-799, MAY 2013.
Web of Science Citations: 8

The periaqueductal gray (PAG) columns have been implicated in controlling stress responses through corticotropin-releasing factor (CRF), which is a neuropeptide with a prominent role in the etiology of fear-and anxiety-related psychopathologies. Several studies have investigated the involvement of dorsal FAG (dPAG) CRF mechanisms in models of unconditioned fear. However, less is known about the role of this neurotransmission in the expression of conditioned fear memories in the dPAG and ventrolateral FAG (vlPAG) columns. We assessed the effects of ovine CRF (oCRF 0.25 and 1.0 mu g/0.2 mu L) locally administered into the dPAG and vlPAG on behavioral (fear-potentiated startle and freezing) and autonomic (arterial pressure and heart rate) responses in rats subjected to contextual fear conditioning. The lower dose injected into the columns promoted proaversive effects, enhanced contextual freezing, increased the blood pressure and heart rate and decreased tail temperature. The lower dose of oCRF into the vlPAG, but not into the dPAG, produced a pronounced enhancement of the fear-potentiated startle response. The results imply that the FAG is a heterogeneous structure that is involved in the coordination of distinct behaviors and autonomic control, suggest PAG involvement in the expression of contextual fear memory as well as implicate the CRF as an important modulator of the neural substrates of fear in the PAG. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/00041-3 - Neurobiology of stress: the sensorimotor gating
Grantee:Marcus Lira Brandão
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/20762-7 - Possible involvement of oxidative/nitrosative stress induced by restraint stress in modulation of conditioned emotional response
Grantee:Alessandra das Graças Fedoce
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/09300-4 - Bed nucleus of the stria terminalis noradrenergic system modulates contextual fear conditionig: possible interaction with CRF and glutamatergic and nitrergic neurotransmission
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants
FAPESP's process: 11/07332-3 - Possible role of dorsal hippocampus on behaviour and autonomic responses during defensive responses: involvement of NMDA receptor/nitric oxide and endocanabinoid
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants