| Full text | |
| Author(s): Show less - |
Barbeiro, Denise Frediani
[1]
;
Barbeiro, Hermes Vieira
[1]
;
Zampieri, Fernando Godinho
[1]
;
Cesar Machado, Marcel Cerqueira
[1]
;
Torggler Filho, Francisco
[1]
;
Gomes Cunha, Debora Maria
[1]
;
Goulart, Alessandra Carvalho
[1]
;
Velasco, Irineu Tadeu
[1]
;
da Cruz Neto, Luiz Monteiro
[1]
;
de Souza, Heraldo Possolo
[1]
;
da Silva, Fabiano Pinheiro
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Dept Emergency Med, BR-05508 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Microbes and Infection; v. 15, n. 5, p. 342-346, MAY 2013. |
| Web of Science Citations: | 20 |
| Abstract | |
Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU) | |
| FAPESP's process: | 09/17731-2 - Markers of infection in critically ill patients |
| Grantee: | Fabiano Pinheiro da Silva |
| Support Opportunities: | Research Grants - Young Investigators Grants |