Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi

Souza, Vanessa A. de; Silva, Rosangela da; Pereira, Ana C.; Royo, Vanessa de A.; Saraiva, Juliana; Montanheiro, Marisa; Souza, Gustavo H. B. de; Silva Filho, Ademar A. da; Grando, Marcella D.; Donate, Paulo M.; et al

Advanced search

Search - Use quotation marks to get a more specific result

Index

Field of knowledge

Start date

Betweenand

(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi

Full text
Author(s): Show less -	Souza, Vanessa A. de ; Silva, Rosangela da ^[2] ; Pereira, Ana C. ; Royo, Vanessa de A. ; Saraiva, Juliana ; Montanheiro, Marisa ; Souza, Gustavo H. B. de ; Silva Filho, Ademar A. da ; Grando, Marcella D. ; Donate, Paulo M. ; et al Total Authors: 11
Document type:	Journal article
Source:	Bioorganic & Medicinal Chemistry Letters; v. 15, n. 2, p. 303-307, Jan. 2005.
Field of knowledge:	Physical Sciences and Mathematics - Chemistry
Abstract
Five (-)-cubebin derivative compounds, (-)-O-acetyl cubebin (3), (-)-O-benzyl cubebin (4), (-)-O-(N,N-dimethylaminoethyl)-cubebin (5), (-)-hinokinin (6) and (-)-6,6'-dinitrohinokinin (7), previously synthesised by our research group, were evaluated on in vitro assay against free amastigote forms of Trypanosoina cruzi, the asogic agent of Chagas' disease. It was observed that 6 was the most active compound (IC50 = 0.7 muM), and that 4 and 5 displayed moderate activity against the parasite, giving IC50 values of 5.7 and 4.7 muM, respectively. In contrast, it was observed that compound 3 was inactive and that 7 displayed low activity with IC50 values of congruent to1.5 x 10(4) and 95.3 muM, respectively. (AU)

Short URL