Slow inotropic response of intact left ventricle to sudden dilation critically depends on a myocardial dialysable factor

Author(s)

Tucci, Paulo J. F. ^[1] ; Faber, Cristiano N. ; Santos, Leonardo dos ; Antonio, Ednei L.

Affiliation

^[1] Universidade Federal de São Paulo (UNIFESP). Campus São Paulo - Vila Clementino. Escola Paulista de Medicina - Brasil

• Document type: Research communication
• Source: Clinical and Experimental Pharmacology and Physiology; v. 34, n. 5, p. 515-516, May 2007.
• Field of knowledge: Health Sciences - Medicine

Abstract

Slow inotropic response following a sudden myocardium stretch seems to be an autocrine/paracrine mechanism the basis of which is not yet completely defined. 2. We compared the canine left ventricle (LV) response to sudden dilation when the LV was supported by the arterial blood of a support dog with when it was supported by an oxygenator + haemodialyser system. 3. A slow inotropic response (SIR) after dilation was seen in all six hearts supported by the donor dog, attaining 87 +/- 6% of immediate increase, whereas a mere 10% SIR occurred in only one out of seven hearts maintained by the oxygenator + haemodialyser. 4. These results indicate that SIR genesis involves one or more renewable components essential to the intracellular calcium gain elicited by stretch. (AU)

• FAPESP's process: 99/04533-4 - Physiology and physiopathology in cardiology
• Grantee: Paulo Jose Ferreira Tucci
• Support Opportunities: Research Projects - Thematic Grants