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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TISs-ST: a web server to evaluate polymorphic translation initiation sites and their reflections on the secretory targets

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Author(s):
Vicentini, Renato ; Menossi, Marcelo [2]
Total Authors: 2
Document type: Journal article
Source: BMC Bioinformatics; v. 8, p. 0-0, May 2007.
Field of knowledge: Biological Sciences - Genetics
Abstract

The nucleotide sequence flanking the translation initiation codon (start codon context) affects the translational efficiency of eukaryotic mRNAs, and may indicate the presence of an alternative translation initiation site (TIS) to produce proteins with different properties. Multitargeting may reflect the translational variability of these other protein forms. In this paper we present a web server that performs computations to investigate the usage of alternative translation initiation sites for the synthesis of new protein variants that might have different functions. An efficient web-based tool entitled TISs-ST (Translation Initiation Sites and Secretory Targets) evaluates putative translation initiation sites and indicates the prediction of a signal peptide of the protein encoded from this site. The TISs-ST web server is freely available to both academic and commercial users and can be accessed at http://ipe.cbmeg.unicamp.br/pub/TISs-ST. The program can be used to evaluate alternative translation initiation site consensus with user-specified sequences, based on their composition or on many position weight matrix models. TISs-ST provides analytical and visualization tools for evaluating the periodic frequency, the consensus pattern and the total information content of a sequence data set. A search option allows for the identification of signal peptides from predicted proteins using the PrediSi software. (AU)

FAPESP's process: 03/07244-0 - Sugarcane transcriptom
Grantee:Glaucia Mendes Souza
Support type: Research Grants - Research Partnership for Technological Innovation - PITE
FAPESP's process: 02/01167-1 - Development of molecular markers based on sugarcane ESTs for the selection of economically important characteristics
Grantee:Anete Pereira de Souza
Support type: Research Grants - Research Partnership for Technological Innovation - PITE