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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding the spectrum of temporal lobe epilepsy: contributions for the development of individualized therapies

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Coan, Ana C. [1] ; Cendes, Fernando [1]
Total Authors: 2
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Neurol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: EXPERT REVIEW OF NEUROTHERAPEUTICS; v. 13, n. 12, p. 1383-1394, DEC 2013.
Web of Science Citations: 10

Mesial temporal lobe epilepsy (TLE) is a subtype of epilepsy in which individuals present with seizure semiology and electroencephalographic characteristics that point to an ictal onset in mesial temporal structures. The diagnosis of TLE involves different etiologies, the most common being hippocampal sclerosis, but up to 20% of TLE patients have no detectable structural lesions on modern MRIs. A variability of antiepileptic drug response and surgical prognosis is observed in TLE. The understanding of the differences among patients with TLE can facilitate the development of individualized and more efficient therapeutics. In this study, we will address the recent contributions of neuroimaging, neurophysiology, genetics and histopathology to the comprehension of the spectrum of TLE with and without MRI signs of hippocampal sclerosis and how the advances in these areas have helped to improve surgical treatments. (AU)

FAPESP's process: 05/56578-4 - Multimodal neuroimaging center for studies in epilepsy
Grantee:Fernando Cendes
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants