Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?

Author(s)

Ponzio, Caroline ^[1] ; Palomino, Zaira ^[1] ; Puccini, Rosana Fiorini ^[2] ; Strufaldi, Maria Wany L. ^[2] ; Franco, Maria C. P. ^{[1, 3]}

Affiliation

^[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Sch Med, Dept Pediat, BR-04023900 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF PEDIATRICS; v. 172, n. 12, p. 1687-1692, DEC 2013.
• Web of Science Citations: 3

Abstract

Recent findings suggest that low-birth-weight children with current obesity are more likely to have higher systolic blood pressure levels and impaired beta-cell function than those who are obese with normal birth weight. It seems possible, however, that concurrent low birth weight with excess weight gain can exacerbate other risk factors for cardiometabolic diseases. The purpose of this study is to investigate the influence of birth weight on the lipid/apolipoprotein profile, visfatin levels, and insulin parameters in overweight/obese children. A cross-sectional study of 68 overweight/obese children was conducted. Among these children, 28 were identified with low birth weight and 40 were of normal birth weight. Blood lipid profile, apolipoproteins, visfatin, glucose, and insulin were measured. Our results show that systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, triglycerides (TG), very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein B and E, insulin, apolipoprotein B/A(1) ratio, and homeostasis model assessment insulin resistance (HOMA-IR) were significantly elevated in overweight/obese low-birth-weight (LBW) children. There was a significant association of the SBP levels with TG (P = 0.027), LDLc (P = 0.001), HOMA-IR (P < 0.001), apolipoprotein B (P = 0.001), and apolipoprotein E (P = 0.039). Conclusion: Our findings suggest that LBW children with overweight or obesity have an additional risk factor for both atherogenic and insulinogenic profile. (AU)

• FAPESP's process: 07/58044-2 - Birth weight and cardiovascular diseases: characterization of risk and genetic factors interrelation by identifying genomic imprinting mechanisms as well as genetic polymorphisms in homocysteine and eNOS pathways
• Grantee: Maria Do Carmo Pinho Franco
• Support Opportunities: Research Grants - Young Investigators Grants