Effects of sleep deprivation during pregnancy on the reproductive capability of the offspring

Author(s)

Alvarenga, Tathiana A. ^[1] ; Aguiar, Marina F. P. ^[1] ; Mazaro-Costa, Renata ^[2] ; Tufik, Sergio ^[1] ; Andersen, Monica L. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

^[2] Univ Fed Gois Goiania, Dept Ciencias Fisiol, Goiania, Go - Brazil

• Document type: Journal article
• Source: Fertility and Sterility; v. 100, n. 6, p. 1752-1757, DEC 2013.
• Web of Science Citations: 8

Abstract

Objective: To investigate the effects of sleep deprivation during pregnancy on the reproductive capability of the offspring. Design: Using a sleep loss model or control home-cage group (male and females rats) to evaluate sexual behavior and hormonal profile in males and females F1 offispring. Setting: Laboratory. Animals(s): First experiment: Pregnant females were exposed to sleep restriction (SR) protocol and the F1 generation was evaluated. Second experiment: male rats were submitted to SR or paradoxical sleep deprivation (PSD) protocol and the F1 generation was evaluated. Intervention(s): Male and female rats were subjected to sleep restriction (SR) for 21 days or paradoxal sleep-deprived (PSD) for 96 hours. Main Outcome Measure(s): Sexual behavior and hormonal levels during the adult phase were analyzed in F1 offspring of female and male rats submitted to sleep loss. Result(s): F1 male offspring of SR females had lower motivation for sex and reduced progesterone concentrations. In contrast, F1 female offspring displayed significantly enhanced proceptivity compared with control offspring. F1 female offspring also demonstrated hypersexuality by mounting the males in the absence of any significant hormonal alterations. F1 male offspring of SR or paradoxically sleep-deprived (PSD) males presented a decline in the sexual response, accompanied by a reduction in testosterone concentrations. Proceptivity was significantly increased among F1 female offspring of PSD and SR males compared with control offspring. Conclusion(s): SR in progenitors may alter sexual behavior of the F1 offspring in adulthood. These findings reveal far-reaching consequences of sleep deprivation, and suggest that parental sleep influences the reproductive capability of subsequent generations. (Fertil Steril (R) 2013;100:1752-7. (C)2013 by American Society for Reproductive Medicine.) (AU)

• FAPESP's process: 11/12325-6 - Effects of sleep deprivation and obstructive sleep apnea syndrome on reproductive function in men
• Grantee: Tathiana Aparecida Fernandes de Alvarenga
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/05396-7 - Consequences of sleep restriction during pregnancy on the development of sensory-motor and sexual behavior in the offspring
• Grantee: Monica Levy Andersen
• Support Opportunities: Regular Research Grants