Synthesis and photophysical evaluations of beta-fused uracil-porphyrin derivatives

Author(s)

Brito Carvalho, Carla Marisa ^[1] ; Fujita, Marta Akemi ^[1] ; Brocksom, Timothy John ^[1] ; de Oliveira, Kleber Thiago ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Tetrahedron; v. 69, n. 47, p. 9986-9993, NOV 25 2013.
• Web of Science Citations: 6

Abstract

New beta-fused uracil-porphyrin conjugates were synthesized by the tetramerization of uracil-pyrroles under acidic conditions. Two different synthetic approaches were systematically studied in order to evaluate their efficiency, as well as the possibility to obtain a single regioisomer. Metallation effects were studied for aggregation in solution, and preliminary photophysical experiments were also performed in order to evaluate the potential of these new compounds. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 11/17177-5 - Total synthesis of new photosensitizers like benzopophyrins with potential activities in photodynamic therapy
• Grantee: Carla Marisa Brito de Carvalho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
• Grantee: Timothy John Brocksom
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/04964-1 - About the synthesis of benzophorphyrins derivatives with potential photosensitizing activities
• Grantee: Marta Akemi Fujita
• Support Opportunities: Scholarships in Brazil - Master