About the synthesis of benzophorphyrins derivatives with potential Photosensitizing Activities

• Grant number: 12/04964-1
• Support type: Scholarships in Brazil - Master
• Effective date (Start): June 01, 2012
• Effective date (End): May 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Kleber Thiago de Oliveira
• Grantee: Marta Akemi Fujita
• Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 08/06619-4 - Synthesis of new photosensitizers with potential aplication in photodynamic therapy, AP.JP

Abstract

This project purposes the synthesis of novel benzoporphyrin type derivatives, in particular a new class of compounds named pirimidinoporphyrins. The main objective is to expand the chemistry of heterocyclic compounds and explore new photossensitizer structures with improved UV-Vis spectra for photodynamic therapy (PDT) applications. From the synthetic perspective, we purpose the construction of novel pirimidinoporphyrin compounds starting from pyrroles containing an uracil core. We will study the uracilpyrrole tetramerization reactions for obtainment of the new cited pirimidinoporphyrins. Initially, we will give focus on the synthesis of tetrapirimidinoporphyrins using four uracilpyrrol units. Nevertheless, approaches involving the synthesis of non-symmetrical systems will also be considered and investigated.In addition, all the compounds will be extensively characterized and physical and photophysical preliminary studies on photodynamic activity will also be performed. The most promising candidates for PDT applications should be further evaluated in association with research groups of PDT area, which collaborate with our recently established group at the Chemistry Department - UFSCar.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, KLEBER T.; MOMO, PATRICIA B.; DE ASSIS, FRANCISCO F.; FERREIRA, MARCO A. B.; BROCKSOM, TIMOTHY J. Chlorins: Natural Sources, Synthetic Developments and Main Applications. CURRENT ORGANIC SYNTHESIS, v. 11, n. 1, p. 42-58, FEB 2014. Web of Science Citations: 31.

BRITO CARVALHO, CARLA MARISA; FUJITA, MARTA AKEMI; BROCKSOM, TIMOTHY JOHN; DE OLIVEIRA, KLEBER THIAGO. Synthesis and photophysical evaluations of beta-fused uracil-porphyrin derivatives. Tetrahedron, v. 69, n. 47, p. 9986-9993, NOV 25 2013. Web of Science Citations: 6.