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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low toxic effects of a whitening strip to cultured pulp cells

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Author(s):
Soares, Diana Gabriela [1] ; Voltoline Pontes, Elaine Cristina [1] ; Dias Ribeiro, Ana Paula [2] ; Basso, Fernanda Goncalves [3] ; Hebling, Josimeri [3] ; de Souza Costa, Carlos Alberto [4]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Araraquara Sch Dent, Dept Dent Mat & Prosthodont, BR-14801903 Araraquara, SP - Brazil
[2] Fed Univ Brasilia, Dept Dent, Brasilia, DF - Brazil
[3] Univ Estadual Paulista UNESP, Araraquara Sch Dent, Dept Orthodont & Pediat Dent, BR-14801903 Araraquara, SP - Brazil
[4] Univ Estadual Paulista UNESP, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: AMERICAN JOURNAL OF DENTISTRY; v. 26, n. 5, p. 283-285, OCT 2013.
Web of Science Citations: 5
Abstract

Purpose: To assess the trans-enamel and trans-dentin toxicity of a 10% hydrogen peroxide (HP) whitening strip to odontoblast-like cells (MDPC-23). Methods: Enamel surfaces of enamel/dentin discs adapted to artificial pulp chambers were subjected to two 30-minute whitening strip applications to obtain indirect extracts (DMEM + bleaching components that diffused across enamel and dentin). The extracts were applied for 1 hour to the cells for 1 or 5 days. A bleaching gel with 35% HP was used as the positive control. Cell viability (MTT assay) and morphology (SEM) as well as the quantity of HP in the extracts were assessed. Results: Discrete cell viability reduction (21.9%) associated with slight alterations in cell morphology occurred after application of the extracts for 5 days to the MDPC-23 cells (Tukey's test; P< 0.05). Lower enamel/dentin diffusion of HP was observed after the use of the whitening strip compared with the bleaching gel (Mann-Whitney; P< 0.05). (AU)

FAPESP's process: 11/12938-8 - New parameters for tooth bleaching: an evaluation of efficacy, citotoxicity and molecular effects
Grantee:Carlos Alberto de Souza Costa
Support Opportunities: Regular Research Grants
FAPESP's process: 11/09385-7 - New parameters for tooth bleaching: an evaluation of efficacy, citotoxicity and molecular effects
Grantee:Diana Gabriela Soares dos Passos
Support Opportunities: Scholarships in Brazil - Doctorate