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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between IL8 haplotypes and pathogen levels in chronic periodontitis

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Author(s):
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Finoti, L. S. [1] ; Corbi, S. C. T. [1] ; Anovazzi, G. [1] ; Teixeira, S. R. L. [2] ; Steffens, J. P. [3] ; Secolin, R. [4] ; Kim, Y. J. [5] ; Orrico, S. R. P. [1] ; Cirelli, J. A. [1] ; Mayer, M. P. A. [2] ; Scarel-Caminaga, R. M. [6]
Total Authors: 11
Affiliation:
[1] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
[3] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil
[4] Univ Campinas UNICAMP, Dept Med Genet, Campinas, SP - Brazil
[5] Univ Santo Amaro, Dept Implantol, Sao Paulo - Brazil
[6] Univ Estadual Paulista, UNESP, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; v. 32, n. 10, p. 1333-1340, OCT 2013.
Web of Science Citations: 8
Abstract

Chronic periodontitis (CP) is considered to be a multifactorial disease influenced by microbial and genetic factors. The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/TTC haplotype is associated with subgingival levels of periodontopathogens. Sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the IL8 haplotype, were evaluated. After clinical periodontal evaluation, each group was subdivided according to the presence (CP) or absence (H) of periodontitis. Four subgingival samples were obtained from CP and two samples per subject from H patients. The levels and proportions of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were analyzed using quantitative real-time polymerase chain reaction (q-PCR). No differences were found in the proportion of periodontopathogenic bacteria between groups with the presence or absence of the IL8 haplotype. However, in the CP groups, the levels of periodontopathogens were significantly higher in the individuals without the IL8 haplotype than in the individuals with the IL8 haplotype. These results suggest that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/TTC haplotype than in patients without this haplotype. (AU)

FAPESP's process: 09/11371-4 - COMPARATIVE INVESTIGATION OF CLINICAL AND MICROBIOLOGICAL DATA BETWEEN GENETICALLY SUSCEPTIBLE INDIVIDUALS AND NOT SUSCETIBLE TO PERIODONTITIS
Grantee:Livia Sertori Finoti
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/08773-3 - Clinical, microbiological and imunological analyses in individuals with genetic susceptibility to periodontal disease
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants
FAPESP's process: 03/10424-0 - Investigation of polymorphisms in the promoter region of interleukin 8 in Brazilian individuals with chronic periodontitits
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants