Protective effect of sodium bicarbonate on radiological contrast medium-induced nephropathy in rats

Author(s)

Fernandes Vattimo, Maria de Fatima ^[1] ; dos Santos, Juliana Guareschi ^[2]

Affiliation

^[1] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Nursing, FAPESP Fellowship, Sao Paulo - Brazil

• Document type: Journal article
• Source: Revista da Escola de Enfermagem da USP; v. 47, n. 3, p. 714-719, JUN 2013.
• Web of Science Citations: 3

Abstract

Radiological iodinated contrasts (IC) agents cause acute kidney injury (AKI). To evaluate the renoprotective effect of sodium bicarbonate (Bic) on renal function (creatinine clearance {[}Clcr], Jaffe, and Clcr mL.min(-1)x100 g(-1)) and the oxidative profile (peroxide excretion, urinary peroxides, urinary malondialdehyde, FOX-2 expression, and thiobarbituric acid reactive substance {[}TBARS; nmol/mg Cr]) in rats treated with an IC agent. Adult male Wistar rats weighing 250-300 g were treated once daily for 5 days with one of the following treatments: saline (0.9%, 3 mL.kg(-1)xday(-1) intraperitoneally {[}i.p.]), IC agent (sodium and meglumine ioxitalamate, 3 mL/kg, i.p.), Bic + Saline (3-mL/kg Bic, i.p., 1 h before and aft er saline treatment), and Bic + IC (3-mL/kg Bic, i.p., 1 h before and after the IC treatment). The IC agent induced AKI, and the antioxidant renoprotective effect of Bic was confirmed (Clcr/TBARS/urinary peroxide: saline group, 0.59 +/- 0.03/0.11 +/- 0.02/1.29 +/- 0.24; Bic + Saline group, 0.58 +/- 0.03/0.13 +/- 0.02/1.32 +/- 0.64; IC group, 0.22 +/- 0.02/0.19 +/- 0.02/4.77 +/- 0.24; Bic + CI group, 0.51 +/- 0.04/0.13 +/- 0.3/1.80 +/- 0.04; p<0.05). The protective effect of Bic in the IC-induced AKI was confirmed; hence, Bic administration may be considered as a therapeutic option for patients undergoing IC-enhanced radiography. (AU)

• FAPESP's process: 10/01008-7 - Role of the sodium bicarbonate on the radiocontrast agent induced nephropathy in rats.
• Grantee: Juliana Guareschi dos Santos
• Support Opportunities: Scholarships in Brazil - Scientific Initiation