| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo - Brazil
[2] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen - Germany
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | DALTON TRANSACTIONS; v. 42, n. 48, p. 16796-16805, 2013. |
| Web of Science Citations: | 11 |
| Abstract | |
Diruthenium(II,III)-tetracarboxylates have shown promising anticancer properties as metallotherapeutics. On the basis of the role that bio-reducing agents may play on the mode of action of ruthenium-based anticancer drugs, we performed detailed kinetic studies on the reaction of ascorbic acid and glutathione with the {[}Ru-2(RCOO)(4)](+) paddlewheel framework by using the non-drug, diaqua complex ion {[}Ru-2(CH3COO)(4)(H2O)(2)](+). In the presence of the reducing agents, the diaqua-Ru-2 species first undergo a ligand substitution reaction by which the axially-coordinated water is displaced by the reducing agent. In both cases, this reaction is followed by an intra-molecular electron transfer process during which the metal-metal center is reduced from Ru-2(5+) to Ru-2(4+) and the reducing agent is oxidized. Product analyses were performed with the application of ESI-MS and H-1-NMR techniques. Rate and activation parameters are reported for the different reaction steps. (AU) | |
| FAPESP's process: | 05/60596-8 - Complex species with potential for application in bio-organics, catalysis, pharmacology and environmental chemistry: conception, preparation, characterization and reactivity |
| Grantee: | Ana Maria da Costa Ferreira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/06592-1 - Anti-inflammatory and antitumor metallotherapeutic drugs: reactivity, properties and interactions with biocompatible hosts |
| Grantee: | Denise de Oliveira Silva |
| Support Opportunities: | Regular Research Grants |