A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging

Author(s)

Lopes, Adriana A. ^[1] ; Pina, Edieidia S. ^[2] ; Silva, Denise B. ^[1] ; Pereira, Ana Maria S. ^[2] ; da Silva, Maria Fatima das Gracas F. ^[3] ; Da Costa, Fernando B. ^[1] ; Lopes, Norberto P. ^[1] ; Pupo, Monica T. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, BR-14040903 Sao Paulo - Brazil

^[2] Univ Ribeirao Preto, Unidade Biotecnol, BR-14096900 Ribeirao Preto - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, Ctr Ciencias Exatas & Tecnol, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: CHEMICAL COMMUNICATIONS; v. 49, n. 85, p. 9989-9991, 2013.
• Web of Science Citations: 8

Abstract

The biosynthetic route for epoxyangelate esters of the sesquiterpene lactones (STL) uvedalin and enhydrin from in vitro cultures of Smallanthus sonchifolius (Asteraceae) was investigated with C-13-precursors for the first time in the literature. Photomicroscope analyses and studies using MALDI-MS imaging confirmed that glandular trichomes accumulate STL. (AU)

• FAPESP's process: 08/09540-0 - New strategies in the search of natural antibiotics: symbiotic microorganisms as sources of compounds and in vivo assay based on Caenorhabditis elegans infection model
• Grantee: Mônica Tallarico Pupo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/01220-6 - Isoprenoid biosynthetic study in Smallanthus sonchifolius and in the endophytic fungus Nigrospora sphaerica associated to the LC-MS monitoring of the sesquiterpene lactone enidrin production in endophytic cultures
• Grantee: Adriana Aparecida Lopes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral