The effect of homogenization method on the properties of carbamazepine microparticles prepared by spray congealing

Author(s)

Martins, Rodrigo Molina ^[1] ; Siqueira, Silvia ^[1] ; Machado, Marcela Olaia ^[1] ; Pedro Freitas, Luis Alexandre ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Apoio Pesquisa Prod Nat & Sintet, BR-14040903 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Journal of Microencapsulation; v. 30, n. 7, p. 692-700, 2013.
• Web of Science Citations: 10

Abstract

The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire (R) 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (499%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D-90) to 62.8 +/- 4.1 mu m and 64.9 +/- 3.3 mu m, respectively, while magnetic stirring produced microparticles with a size of 84.1 +/- 1.4 mu m. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation. (AU)

• FAPESP's process: 08/07115-0 - Development of carbamazepine microparticulated solid dispersions by spray congealing
• Grantee: Rodrigo Molina Martins
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 08/02848-9 - Study on the Preparation of Solid Dispersions containing Low Solubility Pharmaceuticals by Spray Congealing
• Grantee: Luis Alexandre Pedro de Freitas
• Support Opportunities: Regular Research Grants