Biologically Active Eremophilane-Type Sesquiterpenes from Camarops sp., an Endophytic Fungus Isolated from Alibertia macrophylla

Author(s)

Gubiani, Juliana R. ^[1] ; Zeraik, Maria L. ^[1] ; Oliveira, Camila M. ^[2] ; Ximenes, Valdecir F. ^[3] ; Nogueira, Claudio R. ^[1] ; Fonseca, Luiz M. ^[4] ; Silva, Dulce H. S. ^[1] ; Bolzani, Vanderlan S. ^[1] ; Araujo, Angela R. ^[1]

Affiliation

^[1] Univ Estadual Paulista, Dept Quim Organ, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Inst Quim, BR-14800900 Sao Paulo - Brazil

^[2] Univ Fed Amazonas, Inst Ciencias Exatas & Tecnol, Itacoatiara, Amazonas - Brazil

^[3] Univ Estadual Paulista, UNESP, Fac Ciencias, Dept Quim, BR-17033360 Bauru, SP - Brazil

^[4] Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, UNESP, Dept Anal Clin, BR-14801902 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Journal of Natural Products; v. 77, n. 3, p. 668-672, MAR 2014.
• Web of Science Citations: 12

Abstract

Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants