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Bioactive metabolites produced by the endophytic actinobacteria isolated from anthurium urvilleanum from Alcatrazes Island

Grant number: 20/01876-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Laura Amadeu Paulino
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Actinobacteria are known to be prolific producers of secondary metabolites, many of which are biologically active. Despite the diversity of compounds already isolated from actinobacteria, particularly of the genus Streptomyces, the biosynthetic potential of these microorganisms is far from being fully explored. In view of the almost 43 thousand natural products isolated from microorganisms, the isolation of only 69 secondary metabolites of endophytic actinobacteria indicates that these strains are under-explored and/or that the methodologies used to obtain these strains and their metabolites has not been effective. Using liquid chromatography coupled with sequential and high-resolution mass spectrometry for the dereplication of extracts combined with bioassays, helping to prioritize the isolation of new substances, this project proposes to isolate and structurally elucidate new and bio-active secondary metabolites from an endophytic bacterium strain obtained from Anthurium urvilleanum, a plant from the island of Alcatrazes. (AU)